创作:杜海洋 审核:小肠君 03月12日
  • 肠道膨胀诱导的“战斗-逃跑”免疫反应,是秀丽隐杆线虫用于激活免疫途径和引发病原体回避行为的一般机制;
  • 致病菌铜绿假单胞菌定植、排便功能缺陷导致的细菌载量激增会引起肠道膨胀;
  • 肠道膨胀以不依赖于微生物定植的方式激活天然免疫,触发对病原体的免疫行为;
  • 肠道膨胀上调神经内分泌通路,引发线虫产生回避铜绿假单胞菌的行为;
  • DAF-7和NPR-1神经内分泌信号通路,在引发上述病原体回避行为中起作用。

Microbial Colonization Activates an Immune Fight-and-Flight Response via Neuroendocrine Signaling



02-28, Article

Abstract & Authors:展开

The ability to distinguish harmful and beneficial microbes is critical for the survival of an organism. Here, we show that bloating of the intestinal lumen of Caenorhabditis elegans caused by microbial colonization elicits a microbial aversion behavior. Bloating of the intestinal lumen also activates a broad innate immune response, even in the absence of bacterial pathogens or live bacteria. Neuroendocrine pathway genes are upregulated by intestinal bloating and are required for microbial aversion behavior. We propose that microbial colonization and bloating of the intestine may be perceived as a danger signal that activates an immune fight-and-flight response. These results reveal how inputs from the intestine can aid in the recognition of a broad range of microbes and modulate host behavior via neuroendocrine signaling.

First Authors:
Jogender Singh

Correspondence Authors:
Alejandro Aballay

All Authors:
Jogender Singh,Alejandro Aballay