具有抗氧化作用的天然分子对儿童非酒精性脂肪肝的积极作用

创作:李珊珊 审核:玉龙潭 01月11日
纳入80名4-16岁患有非酒精性脂肪肝(NAFLD)的儿童,分为羟基酪醇(HXT)和维生素E治疗组和安慰剂组,干预4个月,最终70名儿童完成试验;
治疗组儿童的胰岛素抵抗、甘油三酯水平、氧化应激参数和脂肪变性程度均下降;
脂肪变性的改善与晚期糖基化终产物和羰基化蛋白的水平有关;
HXT和维生素E联用具有抗氧化作用,或可与饮食结合,用于改善儿童NAFLD相关的肝损伤。
延伸阅读

The antioxidant effects of Hydroxytyrosol and Vitamin E on pediatric NAFLD, in a clinical trial: a new treatment?

羟基酪醇和维生素E对儿童非酒精性脂肪肝的抗氧化作用临床试验:一种新的治疗方法?

10.1089/ars.2018.7704

2018-12-27, Article

Abstract & Authors:展开

Abstract:收起
TRIAL DESIGN: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children. Several studies suggest that the improvement of oxidative stress is suggested as a possible therapeutic strategy for paediatric NASH. We performed a randomized double-blind placebo-controlled trial to test the potential efficacy, assessed by improvement of oxidative-stress parameters and liver ultrasound, and tolerability of a mixture of vitamin E and Hydroxytyrosol (HXT) in adolescents with biopsy-proven NAFLD.
METHODS: 440 consecutive patients were screened, 80 of these with biopsy-proven NAFLD were enrolled. Forty patients received an oral dose of HXT and vitamin E and 40 children received the capsules of placebo, for 4 months.
RESULTS: Seventy patients completed the study. Patients in the treatment arm showed a decrease of insulin-resistance, triglyceride levels, oxidative-stress parameters and steatosis grade. Noteworthy, the steatosis improvement correlates with the levels of advanced glycation end products and carbonylated proteins.
CONCLUSION: The HXT and vitamin E treatment improved the main oxidative-stress parameters, insulin resistance and steatosis in children with NAFLD. The use of two natural molecules that may have antioxidant effects seems a promising strategy that could be easily diet integrated to improve NAFLD related liver damage in children.

First Authors:
Valerio Nobili

Correspondence Authors:
Valerio Nobili,Antonella Smeriglio

All Authors:
Valerio Nobili,Anna Alisi,Antonella Mosca,Annalisa Crudele,Salvatore Zaffina,Marcella Denaro,Antonella Smeriglio,Domenico Trombetta