婴儿出生第一年,肠道和呼吸道菌群的发育动态

创作:Mona 审核:mildbreeze 12月06日
收集82例早产和足月婴儿出生后1年内的直肠、喉、鼻的菌群样本,用DMM模型聚类为群落状态类型(CST) ;
将CST发生与菌群发育和婴儿成熟度测量指标(出生胎龄、周龄和校正胎龄)建立关联,随婴儿成熟,CST的变化存在3种模式;
不同身体部位CST组成差异很大,但任一部位的CST对其他部位的CST有很高的预测性;
不同身体部位的菌群组成两两之间存在典型相关性,近端部位间相关性最强,表明婴儿菌群生态系统的远端连接和协调发展。
延伸阅读
Microbiome [IF:9.133]

Neonatal gut and respiratory microbiota: coordinated development through time and space

新生儿的肠道和呼吸道菌群:通过时间空间协调发展

10-26, Article, 10.1186/s40168-018-0566-5more

Abstract:
BACKGROUND: Postnatal development of early life microbiota influences immunity, metabolism, neurodevelopment, and infant health. Microbiome development occurs at multiple body sites, with distinct community compositions and functions. Associations between microbiota at multiple sites represent an unexplored influence on the infant microbiome. Here, we examined co-occurrence patterns of gut and respiratory microbiota in pre- and full-term infants over the first year of life, a period critical to neonatal development.
RESULTS: Gut and respiratory microbiota collected as longitudinal rectal, throat, and nasal samples from 38 pre-term and 44 full-term infants were first clustered into community state types (CSTs) on the basis of their compositional profiles. Multiple methods were used to relate the occurrence of CSTs to temporal microbiota development and measures of infant maturity, including gestational age (GA) at birth, week of life (WOL), and post-menstrual age (PMA). Manifestation of CSTs followed one of three patterns with respect to infant maturity: (1) chronological, with CST occurrence frequency solely a function of post-natal age (WOL), (2) idiosyncratic to maturity at birth, with the interval of CST occurrence dependent on infant post-natal age but the frequency of occurrence dependent on GA at birth, and (3) convergent, in which CSTs appear first in infants of greater maturity at birth, with occurrence frequency in pre-terms converging after a post-natal interval proportional to pre-maturity. The composition of CSTs was highly dissimilar between different body sites, but the CST of any one body site was highly predictive of the CSTs at other body sites. There were significant associations between the abundance of individual taxa at each body site and the CSTs of the other body sites, which persisted after stringent control for the non-linear effects of infant maturity. Canonical correlations exist between the microbiota composition at each pair of body sites, with the strongest correlations between proximal locations.
CONCLUSION: These findings suggest that early microbiota is shaped by neonatal innate and adaptive developmental responses. Temporal progression of CST occurrence is influenced by infant maturity at birth and post-natal age. Significant associations of microbiota across body sites reveal distal connections and coordinated development of the infant microbial ecosystem.

First Authors:
Alex Grier,Andrew McDavid

Correspondence Authors:
Steven R Gill

All Authors:
Alex Grier,Andrew McDavid,Bokai Wang,Xing Qiu,James Java,Sanjukta Bandyopadhyay,Hongmei Yang,Jeanne Holden-Wiltse,Haeja A Kessler,Ann L Gill,Heidie Huyck,Ann R Falsey,David J Topham,Kristin M Scheible,Mary T Caserta,Gloria S Pryhuber,Steven R Gill