Nature子刊:婴儿食物过敏或与肠道菌群有关

创作:洪翔 审核:Epi汪 02月01日
选择两组无菌小鼠,其中健康组肠道内定植健康婴儿的粪便,而CMA组定植牛奶过敏婴儿的粪便;
健康组小鼠对牛奶的过敏反应更弱;
无论是两组小鼠还是定植前的两组婴儿,其肠道菌群结构均表现出明显差异;
健康组回肠内一种梭菌属(Anaerostipes accae)的丰度增高,可能与预防食物过敏相关;
两组小鼠的回肠上皮的转录酶谱也表现出差异;
肠道内细菌对调节食物抗原的过敏反应至关重要,干预肠道菌群或可预防婴儿食物过敏。
延伸阅读
Nature Medicine [IF:32.621]

Healthy infants harbor intestinal bacteria that protect against food allergy

健康婴儿体内含有可以预防食物过敏的肠道细菌

01-14, Article, 10.1038/s41591-018-0324-zmore

Abstract:
There has been a striking generational increase in life-threatening food allergies in Westernized societies. One hypothesis to explain this rising prevalence is that twenty-first century lifestyle practices, including misuse of antibiotics, dietary changes, and higher rates of Caesarean birth and formula feeding have altered intestinal bacterial communities; early-life alterations may be particularly detrimental. To better understand how commensal bacteria regulate food allergy in humans, we colonized germ-free mice with feces from healthy or cow's milk allergic (CMA) infants. We found that germ-free mice colonized with bacteria from healthy, but not CMA, infants were protected against anaphylactic responses to a cow's milk allergen. Differences in bacterial composition separated the healthy and CMA populations in both the human donors and the colonized mice. Healthy and CMA colonized mice also exhibited unique transciptome signatures in the ileal epithelium. Correlation of ileal bacteria with genes upregulated in the ileum of healthy or CMA colonized mice identified a clostridial species, Anaerostipes caccae, that protected against an allergic response to food. Our findings demonstrate that intestinal bacteria are critical for regulating allergic responses to dietary antigens and suggest that interventions that modulate bacterial communities may be therapeutically relevant for food allergy.

First Authors:
Taylor Feehley,Catherine H Plunkett,Riyue Bao

Correspondence Authors:
Cathryn R Nagler

All Authors:
Taylor Feehley,Catherine H Plunkett,Riyue Bao,Sung Min Choi Hong,Elliot Culleen,Pedro Belda-Ferre,Evelyn Campbell,Rosita Aitoro,Rita Nocerino,Lorella Paparo,Jorge Andrade,Dionysios A Antonopoulos,Roberto Berni Canani,Cathryn R Nagler