Cell子刊:低碳水饮食迅速改变菌群改善脂肪肝
  • 短期低碳水饮食(LCD)干预为肥胖的非酒精性脂肪肝患者带来多种代谢益处,用多组学法分析;
  • LCD显著减少脂肪生成、增强β-氧化(血清β-羟基丁酸浓度大幅上升),使肝脏脂肪含量急剧下降;
  • LCD诱导肠道菌群快速转变,25个菌属丰度显著变化,产叶酸的链球菌属和乳球菌属迅速增多,伴随着血清叶酸水平上升,或与脂代谢、氧化应激和炎症的改善相关;
  • 肝脏中基因表达改变,脂肪酸合成通路下调、叶酸介导的碳代谢和脂肪酸氧化通路上调。
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mildbreeze
过去几十年里,非酒精性脂肪肝(NAFLD)发病率迅速攀升,而低碳水饮食可快速改善NAFLD、帮助减肥。本月Cell Metabolism[IF:18.164]上线了瑞典哥德堡大学大牛Fredrik Bäckhed教授与Borén团队合作的人体研究,使用多组学方法,从菌群和代谢等角度,系统分析了低碳水饮食如何在短短14天内大幅改善NAFLD。他们发现,这种饮食干预可改变肠道菌群以增加叶酸生成,帮助患者改善肝脏脂肪代谢。菌群健康领域不容错过的好研究~ (啰嗦一句:任何以治疗为目的的饮食干预都请遵医嘱)
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延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
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Cell Metabolism [IF:22.415]

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans

限制碳水化合物饮食对人体脂肪肝的快速代谢益处的综合理解

10.1016/j.cmet.2018.01.005

2018-02-07, Article

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Abstract:收起
A carbohydrate-restricted diet is a widely recommended intervention for non-alcoholic fatty liver disease (NAFLD), but a systematic perspective on the multiple benefits of this diet is lacking. Here, we performed a short-term intervention with an isocaloric low-carbohydrate diet with increased protein content in obese subjects with NAFLD and characterized the resulting alterations in metabolism and the gut microbiota using a multi-omics approach. We observed rapid and dramatic reductions of liver fat and other cardiometabolic risk factors paralleled by (1) marked decreases in hepatic de novo lipogenesis; (2) large increases in serum β-hydroxybutyrate concentrations, reflecting increased mitochondrial β-oxidation; and (3) rapid increases in folate-producing Streptococcus and serum folate concentrations. Liver transcriptomic analysis on biopsy samples from a second cohort revealed downregulation of the fatty acid synthesis pathway and upregulation of folate-mediated one-carbon metabolism and fatty acid oxidation pathways. Our results highlight the potential of exploring diet-microbiota interactions for treating NAFLD.

First Authors:
Adil Mardinoglu,Hao Wu

Correspondence Authors:
Fredrik Bäckhed,Jan Boren

All Authors:
Adil Mardinoglu,Hao Wu,Elias Bjornson,Cheng Zhang,Antti Hakkarainen,Sari M Räsänen,Sunjae Lee,Rosellina M Mancina,Mattias Bergentall,Kirsi H Pietiläinen,Sanni Söderlund,Niina Matikainen,Marcus Ståhlman,Per-Olof Bergh,Martin Adiels,Brian D Piening,Marit Granér,Nina Lundbom,Kevin J Williams,Stefano Romeo,Jens Nielsen,Michael Snyder,Mathias Uhlen,Göran Bergström,Rosie Perkins,Hanns-Ulrich Marschall,Fredrik Bäckhed,Marja-Riitta Taskinen,Jan Boren

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