乳脂肪摄入的生物标志物与2型糖尿病的关联

创作:梁婷 审核:mildbreeze 2018年10月25日
选取来自12个国家的16个前瞻性队列进行荟萃分析,平均随访9年,63682名参与者中发生15180例糖尿病(T2D);
血液和脂肪组织中,乳脂肪摄入的潜在生物标志物(十五烷酸、十七烷酸、反式棕榈油酸,及其总和)的较高水平,与较低的T2D发生率相关;
校正潜在混杂因素后的分析显示,较高水平的3个标志物及其总和(第90百分位),与较低水平(第10百分位)相比,T2D发生率分别降低20%、35%、18%和29%;
这种相关性在女性中更强。
延伸阅读
PLoS Medicine [IF:11.675]

Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies

乳脂肪摄入的脂肪酸生物标志物和2型糖尿病发病率:对前瞻性队列研究的合并分析

2018-10-01, Article, 10.1371/journal.pmed.1002670more

Abstract:
BACKGROUND: We aimed to investigate prospective associations of circulating or adipose tissue odd-chain fatty acids 15:0 and 17:0 and trans-palmitoleic acid, t16:1n-7, as potential biomarkers of dairy fat intake, with incident type 2 diabetes (T2D).
METHODS AND FINDINGS: Sixteen prospective cohorts from 12 countries (7 from the United States, 7 from Europe, 1 from Australia, 1 from Taiwan) performed new harmonised individual-level analysis for the prospective associations according to a standardised plan. In total, 63,682 participants with a broad range of baseline ages and BMIs and 15,180 incident cases of T2D over the average of 9 years of follow-up were evaluated. Study-specific results were pooled using inverse-variance-weighted meta-analysis. Prespecified interactions by age, sex, BMI, and race/ethnicity were explored in each cohort and were meta-analysed. Potential heterogeneity by cohort-specific characteristics (regions, lipid compartments used for fatty acid assays) was assessed with metaregression. After adjustment for potential confounders, including measures of adiposity (BMI, waist circumference) and lipogenesis (levels of palmitate, triglycerides), higher levels of 15:0, 17:0, and t16:1n-7 were associated with lower incidence of T2D. In the most adjusted model, the hazard ratio (95% CI) for incident T2D per cohort-specific 10th to 90th percentile range of 15:0 was 0.80 (0.73-0.87); of 17:0, 0.65 (0.59-0.72); of t16:1n7, 0.82 (0.70-0.96); and of their sum, 0.71 (0.63-0.79). In exploratory analyses, similar associations for 15:0, 17:0, and the sum of all three fatty acids were present in both genders but stronger in women than in men (pinteraction < 0.001). Whereas studying associations with biomarkers has several advantages, as limitations, the biomarkers do not distinguish between different food sources of dairy fat (e.g., cheese, yogurt, milk), and residual confounding by unmeasured or imprecisely measured confounders may exist.
CONCLUSIONS: In a large meta-analysis that pooled the findings from 16 prospective cohort studies, higher levels of 15:0, 17:0, and t16:1n-7 were associated with a lower risk of T2D.

First Authors:
Fumiaki Imamura

Correspondence Authors:
Fumiaki Imamura

All Authors:
Fumiaki Imamura,Amanda Fretts,Matti Marklund,Andres V Ardisson Korat,Wei-Sin Yang,Maria Lankinen,Waqas Qureshi,Catherine Helmer,Tzu-An Chen,Kerry Wong,Julie K Bassett,Rachel Murphy,Nathan Tintle,Chaoyu Ian Yu,Ingeborg A Brouwer,Kuo-Liong Chien,Alexis C Frazier-Wood,Liana C Del Gobbo,Luc Djoussé,Johanna M Geleijnse,Graham G Giles,Janette de Goede,Vilmundur Gudnason,William S Harris,Allison Hodge,Frank Hu,InterAct Consortium,Albert Koulman,Markku Laakso,Lars Lind,Hung-Ju Lin,Barbara McKnight,Kalina Rajaobelina,Ulf Risérus,Jennifer G Robinson,Cécilia Samieri,David S Siscovick,Sabita S Soedamah-Muthu,Nona Sotoodehnia,Qi Sun,Michael Y Tsai,Matti Uusitupa,Lynne E Wagenknecht,Nick J Wareham,Jason Hy Wu,Renata Micha,Nita G Forouhi,Rozenn N Lemaitre,Dariush Mozaffarian