饮食与抑郁症的关系

创作:Echo 审核:可乐 12月06日
先天缺陷和后天压力等多种因素会协同导致抑郁,抑制促炎因子或兴奋下丘脑-垂体-肾上腺轴是治疗抑郁的关键机制;
饮食经肠道菌群的代谢产物可通过肠神经系统、免疫系统或血液循环直接或间接影响大脑,进而影响抑郁,但其因果关系尚不明确;
地中海饮食结构(膳食富含水果、蔬菜、五谷杂粮)可增加肠道微生物多样性,有助于减轻抑郁症状;
抑郁症患者应主要摄入富含谷物和膳食纤维的饮食,限制摄入精制糖类同时配合适当的运动保健。
延伸阅读
Clinical Nutrition [IF:5.496]

Feeding melancholic microbes: MyNewGut recommendations on diet and mood

“新肠道项目”饮食与情绪建议:喂养抑郁的微生物

11-17, Review, 10.1016/j.clnu.2018.11.010more

Abstract:
Depression is a highly prevalent disorder which exerts a major economic impact in all European countries. The brain-gut-microbiota axis has been described as a new paradigm for advancing understanding and treatment of the disorder. There is now over-whelming evidence to support the fact that gut microbes have a major impact on central neurochemistry and behaviour, especially stress related disorders such as depression. Recent studies indicate that patients with depression have a gut dysbiosis. The reason for this dysbiosis is uncertain. Over recent decades, dietary patterns in Europe and elsewhere have undergone major compositional changes, with increased intakes of red meat, high fat foods, and refined sugars. Individuals who consume a Mediterranean diet have lower rates of depression and a recent study suggests that a Mediterranean diet may have antidepressant properties. Assuming this to be the case, which components of the Mediterranean diet mediate the effects? Highly levels of polyphenols or polyunsaturated fatty acids are obvious candidates. We in the MyNewGut consortium recommend that patients with depression or vulnerability to depression should be encouraged to enhance a plant-based diet with a high content of grains/fibres and fish.

First Authors:
Timothy G Dinan

Correspondence Authors:
Timothy G Dinan

All Authors:
Timothy G Dinan,Catherine Stanton,Caitriona Long-Smith,Paul Kennedy,John F Cryan,Caitlin SM Cowan,María Carmen Cenit,Jan-Willem van der Kamp,Yolanda Sanz