Nature子刊:基于性状的婴儿肠道菌群演替模式

创作:李丹宜 审核:李丹宜 02月11日
开发一种基于系统发生的微生物性状推断方法,涉及12个性状,用该方法分析56名婴儿出生头三年肠道微生物组演替模式;
婴儿出生第一年内,肠道菌群有明显的性状变化趋势,如:耐氧和有鞭毛的微生物逐渐减少,生长较慢和形成孢子的微生物逐渐增多,且受分娩方式和抗生素用药影响;
随着婴儿发育,基于分类学和基于性状的肠道菌群组成,在不同个体间均趋于相似,但后者稳定得更早,表明后续的分类学演替在特定性状方面存在功能冗余。
延伸阅读
Nature Communications [IF:12.353]

Trait-based community assembly and succession of the infant gut microbiome

婴儿肠道微生物组的基于性状的群落构建和演替

02-01, Article, 10.1038/s41467-019-08377-wmore

Abstract:
The human gut microbiome develops over early childhood and aids in food digestion and immunomodulation, but the mechanisms driving its development remain elusive. Here we use data curated from literature and online repositories to examine trait-based patterns of gut microbiome succession in 56 infants over their first three years of life. We also develop a new phylogeny-based approach of inferring trait values that can extend readily to other microbial systems and questions. Trait-based patterns suggest that infant gut succession begins with a functionally variable cohort of taxa, adept at proliferating rapidly within hosts, which gradually matures into a more functionally uniform cohort of taxa adapted to thrive in the anoxic gut and disperse between anoxic patches as oxygen-tolerant spores. Trait-based composition stabilizes after the first year, while taxonomic turnover continues unabated, suggesting functional redundancy in the traits examined. Trait-based approaches powerfully complement taxonomy-based approaches to understanding the mechanisms of microbial community assembly and succession.

First Authors:
John Guittar

Correspondence Authors:
John Guittar

All Authors:
John Guittar,Ashley Shade,Elena Litchman