• 关于菌群调控局部和全身性免疫反应的综述:
  • 菌群对固有和获得性免疫都有影响;
  • 这不仅在肠道,在全身各部位都是如此;
  • 本文列示菌群调节宿主抵抗肠外感染的证据,描绘这其中的机制,包括模式识别受体的核心作用和尚待解答的关键性问题。
蓝灿辉 | 热心肠先生
Immunology [IF:4.147]

The regulation of host defences to infection by the microbiota



2016-06-17, Review

Abstract & Authors:展开

The skin and mucosal epithelia of humans and other mammals are permanently colonised by large microbial communities (the microbiota). Due to this life-long association with the microbiota, these microbes have an extensive influence over the physiology of their host organism. It is now becoming apparent that nearly all tissues and organ systems, whether in direct contact with the microbiota, or in deeper host sites, are under microbial influence. The immune system is perhaps the most profoundly affected, with the microbiota programming both its innate and adaptive arms. The regulation of immunity by the microbiota helps protect the host against intestinal and extra-intestinal infection by many classes of pathogen. In this review, we will discuss the experimental evidence supporting a role for the microbiota in regulating host defences to extra-intestinal infection, draw together common mechanistic themes, including the central role of pattern recognition receptors, and outline outstanding questions which need to be answered. This article is protected by copyright. All rights reserved.

First Authors:
Rebecca L Brown

Correspondence Authors:
Thomas B Clarke

All Authors:
Rebecca L Brown,Thomas B Clarke