肠道菌群或与肥胖人群氧化应激水平相关

创作:药农 审核:JIAN 剑 07月11日
本文目的:分析68名健康成年人(20名正常体重)肥胖、饮食、氧化压力、炎症和肠道菌群之间的关系。
结果:肥胖患者体内丙二醛水平、C-反应蛋白、血清瘦素、葡萄糖、脂肪百分比及乳酸菌水平较高。
聚类分析将体重指数、脂肪量、葡萄糖、LDL/HDL之比、瘦素、丙二醛和C-反应蛋白分为两类。
拟杆菌-普雷沃氏菌-卟啉单胞菌水平较低的一组,MDA和C-反应蛋白水平较高;食物频率问卷发现饮食中水果、干果和鱼摄入较少。
延伸阅读
Nutrients [IF:4.196]

Different Intestinal Microbial Profile in Over-Weight and Obese Subjects Consuming a Diet with Low Content of Fiber and Antioxidants

消费低纤维饮食的超重和肥胖受试者肠道菌群谱及抗氧化活性研究

2017-05-27, Article, 10.3390/nu9060551more

Abstract:
Obesity has been related to an increased risk of multiple diseases in which oxidative stress and inflammation play a role. Gut microbiota has emerged as a mediator in this interaction, providing new mechanistic insights at the interface between fat metabolism dysregulation and obesity development. Our aim was to analyze the interrelationship among obesity, diet, oxidative stress, inflammation and the intestinal microbiota in 68 healthy adults (29.4% normal-weight). Diet was assessed through a food frequency questionnaire and converted into nutrients and dietary compounds using food composition tables. The intestinal microbiota was assessed by quantitative PCR, fecal short chain fatty acids by gas chromatography and serum biomarkers by standard protocols. Higher levels of malondialdehyde (MDA), C reactive protein (CRP), serum leptin, glucose, fat percentage and the intestinal Lactobacillus group were found in the obese people. Cluster analysis of body mass index, fat mass, glucose, LDL/HDL ratio, leptin, MDA and CRP classified the subjects into two groups. The levels of the intestinal Bacteroides-Prevotella-Porphyromonas group were lower in the cluster and linked to a higher pro-oxidant and pro-inflammatory status, whose individuals also had lower intake of fruits, dried fruits, and fish. These results could be useful for designing strategies targeted to obesity prevention.

First Authors:
Tania Fernández-Navarro

Correspondence Authors:
Sonia González

All Authors:
Tania Fernández-Navarro,Nuria Salazar,Isabel Gutiérrez-Díaz,Clara G de Los Reyes-Gavilán,Miguel Gueimonde,Sonia González