女孩的童年不幸,影响很长远

创作:洪翔 审核:Epi汪 01月11日
纳入48名孕妇,调查其儿童期不良生活事件(包括忽视、虐待、慢性家庭压力等,ACE)情况,收集粪便样本,进行应激测试并检测炎症因子;
多ACE(经历≥2次)的孕妇肠道菌群中普氏菌属相对丰度较高;
孕期应激反应模式的不同与肠道菌群有关;
多ACE孕妇如果摄入较多ω-3多不饱和脂肪酸可以调节包括白介素6在内的炎症反应水平,使其趋于正常;
孕期炎症反应对母婴健康均有影响,应关注孕妇ACE对肠脑轴的影响以及饮食的调节作用。
延伸阅读

Childhood Adversity Impact on Gut Microbiota and Inflammatory Response to Stress During Pregnancy

儿童期不良生活事件对孕期肠道菌群以及应激炎症反应的影响

2018-11-03, Article, 10.1016/j.bbi.2018.11.005more

Abstract:
BACKGROUND: Adverse childhood experiences (ACEs), such as abuse or chronic stress, program an exaggerated adult inflammatory response to stress. Emerging rodent research suggests that the gut microbiome may be a key mediator in the association between early life stress and dysregulated glucocorticoid-immune response. However, ACE impact on inflammatory response to stress, or on the gut microbiome, have not been studied in human pregnancy, when inflammation increases risk of poor outcomes. The aim of this study was to assess the relationships among ACE, the gut microbiome, and cytokine response to stress in pregnant women.
METHODS: Physically and psychiatrically healthy adult pregnant women completed the Adverse Childhood Experiences Questionnaire (ACE-Q) and gave a single stool sample between 20 and 26 weeks gestation. Stool DNA was isolated and 16S sequencing was performed. Three 24-hour food recalls were administered to assess dietary nutrient intake. A subset of women completed the Trier Social Stress Test (TSST) at 22-34 weeks gestation; plasma interleukin-6 (IL-6), interleukin-1β (IL-1β), high sensitivity C-reactive protein (hsCRP), tumor necrosis factor α (TNF-α), and cortisol were measured at four timepoints pre and post stressor, and area under the curve (AUC) was calculated.
RESULTS: Forty-eight women completed the ACE-Q and provided stool; 19 women completed the TSST. Women reporting 2 or more ACEs (high ACE) had greater differential abundance of gut Prevotella than low ACE participants (q=5.7x10^-13). Abundance of several gut taxa were significantly associated with cortisol, IL-6, TNF-α and CRP AUCs regardless of ACE status. IL-6 response to stress was buffered among high ACE women with high intake of docosahexaenoic acid (DHA) (p=0.03) and eicosapentaenoic acid (EPA) (p=0.05).
DISCUSSION: Our findings suggest that multiple childhood adversities are associated with changes in gut microbiota composition during pregnancy, and such changes may contribute to altered inflammatory and glucocorticoid response to stress. While preliminary, this is the first study to demonstrate an association between gut microbiota and acute glucocorticoid-immune response to stress in a clinical sample. Finally, exploratory analyses suggested that high ACE women with high dietary intake of ω-3 polyunsaturated fatty acids (PUFAs) had a dampened inflammatory response to acute stress, suggesting potentially protective effects of ω-3s in this high-risk population. Given the adverse effects of inflammation on pregnancy and the developing fetus, mechanisms by which childhood adversity influence the gut-brain axis and potential protective factors such as diet should be further explored.

First Authors:
Liisa Hantsoo

Correspondence Authors:
Liisa Hantsoo

All Authors:
Liisa Hantsoo,Eldin Jašarević,Stephanie Criniti,Brendan McGeehan,Ceylan Tanes,Mary D Sammel,Michal A Elovitz,Charlene Compher,Gary Wu,C Neill Epperson