赵立平+陈卫+张和平团队:东西南北中,国人菌不同!

分析不同人群肠道菌群结构,了解共生菌如何维持宿主健康:
对314名健康年轻人进行粪便菌群结构调查,覆盖中国不同省市地区和民族;
九种合成短链脂肪酸的属在所有人中都被发现;
这九种微生物的分布根据宿主的民族、地理和生活方式仍有不同;
这些共有菌群是宿主健康不可或缺的成分。
延伸阅读
ISME Journal [IF:9.52]

A phylo-functional core of gut microbiota in healthy young Chinese cohorts across lifestyles, geography and ethnicities

中国不同生活方式、地域和民族健康年轻人中的肠道菌群核心功能

2015-02-03, Article, 10.1038/ismej.2015.11more

Abstract:
Structural profiling of healthy human gut microbiota across heterogeneous populations is necessary for benchmarking and characterizing the potential ecosystem services provided by particular gut symbionts for maintaining the health of their hosts. Here we performed a large structural survey of fecal microbiota in 314 healthy young adults, covering 20 rural and urban cohorts from 7 ethnic groups living in 9 provinces throughout China. Canonical analysis of unweighted UniFrac principal coordinates clustered the subjects mainly by their ethnicities/geography and less so by lifestyles. Nine predominant genera, all of which are known to contain short-chain fatty acid producers, co-occurred in all individuals and collectively represented nearly half of the total sequences. Interestingly, species-level compositional profiles within these nine genera still discriminated the subjects according to their ethnicities/geography and lifestyles. Therefore, a phylogenetically diverse core of gut microbiota at the genus level may be commonly shared by distinctive healthy populations as functionally indispensable ecosystem service providers for the hosts.

First Authors:
Jiachao Zhang,Zhuang Guo,Zhengsheng Xue,Zhihong Sun,Menghui Zhang

Correspondence Authors:
Liping Zhao,Wei Chen,Heping Zhang

All Authors:
Jiachao Zhang,Zhuang Guo,Zhengsheng Xue,Zhihong Sun,Menghui Zhang,Lifeng Wang,Guoyang Wang,Fang Wang,Jie Xu,Hongfang Cao,Haiyan Xu,Qiang Lv,Zhi Zhong,Yongfu Chen,Sudu Qimuge,Bilige Menghe,Yi Zheng,Liping Zhao,Wei Chen,Heping Zhang