孕期注意饮食,产后更健康

创作:洪翔 审核:Epi汪 01月11日
将孕期母鼠随机分为对照组和高脂饮食组,高脂组体重增长明显高于对照组;
分娩后,两组常规饲料喂养,高脂组母鼠体重迅速恢复到和对照组相同的水平;
但3个月后,高脂组母鼠体重快速增长,在9个月时已是对照组的2倍;
其内脏脂肪和皮下脂肪增多,能量消耗降低,在脂肪组织中雌激素受体α水平(ERα)降低,并检测到ERα甲基化;
孕期的高脂饮食可能通过改变表观遗传学调节雌激素信号,对产后能量代谢产生长期影响。
延伸阅读

High-fat feeding reprograms maternal energy metabolism and induces long-term postpartum obesity in mice

高脂肪喂养可调节母鼠能量代谢,诱导小鼠产后长期肥胖

01-08, Article, 10.1038/s41366-018-0304-xmore

Abstract:
BACKGROUND: Excessive gestational weight gain (EGWG) closely associates with postpartum obesity. However, the causal role of EGWG in postpartum obesity has not been experimentally verified. The objective of this study was to determine whether and how EGWG causes long-term postpartum obesity.
METHODS: C57BL/6 mice were fed with high-fat diet during gestation (HFFDG) or control chow, then their body composition and energy metabolism were monitored after delivery.
RESULTS: We found that HFFDG significantly increased gestational weight gain. After delivery, adiposity of HFFDG-treated mice (Preg-HF) quickly recovered to the levels of controls. However, 3 months after parturition, Preg-HF mice started to gain significantly more body fat even with regular chow. The increase of body fat of Preg-HF mice was progressive with aging and by 9 months after delivery had increased 2-fold above the levels of controls. The expansion of white adipose tissue (WAT) of Preg-HF mice was manifested by hyperplasia in visceral fat and hypertrophy in subcutaneous fat. Preg-HF mice developed low energy expenditure and UCP1 expression in interscapular brown adipose tissue (iBAT) in later life. Although blood estrogen concentrations were similar between Preg-HF and control mice, a significant decrease in estrogen receptor α (ERα) expression and hypermethylation of the ERα promoter was detected in the fat of Preg-HF mice 9 months after delivery. Interestingly, hypermethylation of ERα promoter and low ERα expression were only detected in adipocyte progenitor cells in both iBAT and WAT of Preg-HF mice at the end of gestation.
CONCLUSIONS: These results demonstrate that HFFDG causes long-term postpartum obesity independent of early postpartum fat retention. This study also suggests that HFFDG adversely programs long-term postpartum energy metabolism by epigenetically reducing estrogen signaling in both BAT and WAT.

First Authors:
Liping Qiao

Correspondence Authors:
Jianhua Shao

All Authors:
Liping Qiao,Kayee Chu,Jean-Sebastien Wattez,Samuel Lee,Hongfei Gao,Gen-Sheng Feng,William W Hay,Jianhua Shao