创作:小肠君 审核:小肠君 11月30日
Nature Immunology [IF:21.809]

Sex-hormone-driven innate antibodies protect females and infants against EPEC infection


09-24, Article, 10.1038/s41590-018-0211-2more

Females have an overall advantage over males in resisting Gram-negative bacteremias, thus hinting at sexual dimorphism of immunity during infections. Here, through intravital microscopy, we observed a sex-biased difference in the capture of blood-borne bacteria by liver macrophages, a process that is critical for the clearance of systemic infections. Complement opsonization was indispensable for the capture of enteropathogenic Escherichia coli (EPEC) in male mice; however, a faster complement component 3–independent process involving abundant preexisting antibodies to EPEC was detected in female mice. These antibodies were elicited predominantly in female mice at puberty in response to estrogen regardless of microbiota-colonization conditions. Estrogen-driven antibodies were maternally transferrable to offspring and conferred protection during infancy. These antibodies were conserved in humans and recognized specialized oligosaccharides integrated into the bacterial lipopolysaccharide and capsule. Thus, an estrogen-driven, innate antibody-mediated immunological strategy conferred protection to females and their offspring.

First Authors:
Zhutian Zeng

Correspondence Authors:
Craig N Jenne,Paul Kubes

All Authors:
Zhutian Zeng,Bas G J Surewaard,Connie H Y Wong,Christopher Guettler,Bjӧrn Petri,Regula Burkhard,Madeleine Wyss,Hervé Le Moual,Rebekah Devinney,Graham C Thompson,Jaime Blackwood,Ari R Joffe,Kathy D McCoy,Craig N Jenne,Paul Kubes