Nature子刊:雌激素诱导的天然抗体帮助母婴抵御EPEC感染

创作:小肠君 审核:小肠君 11月30日
肝巨噬细胞捕获血液中细菌的能力男女有别,由雌激素诱导、天然抗体介导的免疫机制帮助雌性及子女抵御肠道致病性大肠杆菌(EPEC)感染;
母鼠体内预存有大量抗EPEC抗原,巨噬细胞不依赖补体c3即可快速捕获EPEC,而公鼠需要依赖补体调理作用;
预存的EPEC抗体主要在青春期由雌激素诱导产生,与肠道菌群定植状态无关;
这类抗体可传递给子女,在婴儿期形成免疫保护;
人类中存在同源抗体,可识别整合在细菌脂多糖和荚膜中的特定寡糖。
延伸阅读
Nature Immunology [IF:21.809]

Sex-hormone-driven innate antibodies protect females and infants against EPEC infection

性激素介导的天然抗体帮助女性和婴儿抵御肠道致病性大肠杆菌感染

09-24, Article, 10.1038/s41590-018-0211-2more

Abstract:
Females have an overall advantage over males in resisting Gram-negative bacteremias, thus hinting at sexual dimorphism of immunity during infections. Here, through intravital microscopy, we observed a sex-biased difference in the capture of blood-borne bacteria by liver macrophages, a process that is critical for the clearance of systemic infections. Complement opsonization was indispensable for the capture of enteropathogenic Escherichia coli (EPEC) in male mice; however, a faster complement component 3–independent process involving abundant preexisting antibodies to EPEC was detected in female mice. These antibodies were elicited predominantly in female mice at puberty in response to estrogen regardless of microbiota-colonization conditions. Estrogen-driven antibodies were maternally transferrable to offspring and conferred protection during infancy. These antibodies were conserved in humans and recognized specialized oligosaccharides integrated into the bacterial lipopolysaccharide and capsule. Thus, an estrogen-driven, innate antibody-mediated immunological strategy conferred protection to females and their offspring.

First Authors:
Zhutian Zeng

Correspondence Authors:
Craig N Jenne,Paul Kubes

All Authors:
Zhutian Zeng,Bas G J Surewaard,Connie H Y Wong,Christopher Guettler,Bjӧrn Petri,Regula Burkhard,Madeleine Wyss,Hervé Le Moual,Rebekah Devinney,Graham C Thompson,Jaime Blackwood,Ari R Joffe,Kathy D McCoy,Craig N Jenne,Paul Kubes