赵立平等:如何解析肠道菌群在饮食与健康中的作用

临床试验和限菌动物研究表明,肠道菌群至少一定程度上影响健康;
确定关键菌株是菌群因果性研究中的重要环节:首先鉴定出作为功能群的共现菌株,然后分离功能群成员,用动物模型确定特定菌株对宿主的影响;
解析关键菌株与宿主互作的生化机制,需组合应用体外培养、动物模型和临床试验;
饮食为肠道菌群施加选择压力,导致的优势功能群可改变肠道环境,进而影响菌群其它成员;
通过饮食影响菌群的“菌群营养学”,将是新型疗法的核心。
延伸阅读
Genome Medicine [IF:8.898]

Causality in dietary interventions-building a case for gut microbiota

膳食干预中的因果性——为肠道菌群建立一个案例

2018-08-01, Comment, 10.1186/s13073-018-0573-ymore

Abstract:
We provide a conceptual framework to establish a causal link between diet, gut microbiota, and health. Identifying the key strains that mediate microbe-host interactions and understanding the mechanisms involved and the ecology of these strains are critical to translating gut microbiome research into clinical applications and to advancing a new concept of "microbiome nutrition".

First Authors:
Yan Y Lam

Correspondence Authors:
Liping Zhao

All Authors:
Yan Y Lam,Chenhong Zhang,Liping Zhao